It is therefore imperative to find the best possible combination of alternative plasticizer and storage solution such that red cell component quality remains unaffected after the transition. As such, in the absence of DEHP, hemolysis levels increase during storage of red cells. This derives from the membrane-stabilizing effect of DEHP. Although there is a lack of evidence that DEHP leaching from collection systems significantly impacts on plasma and platelet component quality, certainly red cell components are affected. Therefore, manufacturers and blood establishments are jointly preparing for the introduction of non-DEHP blood bag systems. As a consequence, the MDR (Medical Device Regulation Regulation 2017/745), has banned the use of DEHP in medical devices above 0.1% (w/w), with a current sunset date of May 2025. There are concerns that exposure to DEHP may be toxic to humans, as in vivo animal studies have shown developmental and reproductive impairment to occur when chronically exposed to high dosages of DEHP. DEHP is non-covalently bound to the PVC polymer and therefore leaches into the blood components. de Korte 1 1Product and Process Development, Sanquin, Amsterdam, The Netherlandsīlood bags are manufactured from polyvinylchloride (PVC) to which plasticizers such as di(2-ethylhexyl)-phthalate (DEHP) are added to optimize the physical properties and prevent leakage during production of components. Academy Session 1 - Blood components - What's new with components? AD01-L01 How I validate non-DEHP components T. PL03-L02 Current curative therapies for thalassaemia L. Plenary Session 3 - Gene therapy in hemaglobinopathies PL03-L01 Methods of gene therapy or functional genomics of globin gene regulation S. PL02-L02 Associations between abo and RHD blood group and disease risk T. This talk will provide an overview of the complex interplay of blood groups in infectious diseases, with specific examples of how these concepts contribute to the specific epidemiology and pathophysiology of disease.
Finally, several blood groups have been shown to modulate the host immune response to infection through regulation of complement, toll receptors, cell signalling, leukocyte recruitment and phagocytosis. Blood groups can also mask, downregulate or mutate receptor sites, protecting the host against infection. Blood groups can influence disease risk by serving as receptors on red cells and other tissues, playing a direct role in colonization, infection and tissue injury. Today, high throughput molecular methods and advanced computing algorithms allow large scale studies and more nuanced understanding of the potential role of blood groups in the epidemiology of many infectious diseases.
Blood groups were particularly attractive early genetic markers due to the ease of collecting peripheral blood for study but restricted by limited reagents for serologic phenotyping. Since the discovery of ABO, blood group antigens have been studied as potential ‘genetic biomarkers’ for a host of microbial, viral, parasitic and fungal infections. Cooling 1 1Pathology, University of Michigan, Ann Arbor, USA
Plenary Session 2 - Infections & blood groups count - The look of a red blood cell and what it means to bugs PL02-L01 Blood groups in infection and host susceptibility L. Plenary Session 1 - Are red blood cells immune cells? A new way to think about red blood cells PL01-L01 Abstract Withdrawn PL01-L02 Human red blood cells as DNA sensors N.